Auricularia auricula extract free#

Auricularia auricula extract free#

It is known to exhibit antioxidant properties to prevent free radical-induced oxidative damages balance the blood glucose and lipid levels to alleviate diabetes, hyperlipidemia, and obesity stimulate macrophage and inflammatory cytokines to prevent inflammation exhibit anti-cancer properties by stimulating cellular apoptosis and prevent gut microbial dysbiosis by stimulating the growth of healthy gut microbiota. Various in vitro and in vivo studies have shown that Jew's ear exhibits numerous health-promoting properties. It contains high levels of melanin, carbohydrates, fiber, protein, amino acids, ergosterol, and ascorbic acids, and a very lower level of fat. Jew's ear is an important cultivated edible mushroom. For that, a strategic partnership among taxonomists, biochemists, pharmacists, farmers, and food experts is highly required to promote Auricularia-based natural products. However, the study identifies some less explored areas such as estimation of farming practices on nutraceuticals quality, purification of bioactive component, and exploration of mechanism of action in vivo. In this backdrop, the present exhaustive review aims to explore species specific ethnic importance, wide range of cultivation techniques replacing traditional method, detailed proximate composition, and evidence based multifunctional therapeutic effects. The easy domestication process thus magnified popularity of ear mushrooms, particularly in recent times, which has a positive effect on edible fungus market demanding an updated summary. Consequently, they are the first mushroom to be cultivated and now rank fourth in worldwide production. The fruiting bodies are translucent, brown to white in color, possess unique morphology of ear shape and jelly-like consistency gifting them various colloquial names like “ear mushroom” or “jelly mushroom.” Most of the species are edible however, consumption of few members, namely Auricularia auricula-judae (Bull.) Quél. Taken together, our study results demonstrated that the DCMF may be used as a functional additive for enhancing antioxidant activities and suppressing tumor growth in the body.Īuricularia is an important genus among jelly fungi growing on woods of deciduous trees and shrubs globally. Semiquantitative reverse transcription polymerase chain reaction analysis demonstrated that DCMF induced cytotoxicity or tumor cell apoptosis as a result of the downregulation of Bcl-2 expression and p53 overexpression. These findings indicate that other unknown components of the DCMF also are responsible for the cytotoxic effects of DCMF against tumor cells. However, we found that diazane alone had a lower level of antitumor activity than the DCMF.

Based on the results of this analysis, an antitumor active component (diazane) was identified in the DCMF. We further analyzed the DCMF composition by gas chromatography−coupled mass spectroscopy. The DCMF was found to have more potent antitumor activity against broncheoalveolar cancer (half maximal inhibitory concentration = 57.2 µg/mL) and gastric cancer cells (half maximal inhibitory concentration = 73.2 µg/mL) compared to the other solvent fractions, although all fractions inhibited the proliferation of the tumor cells in a dose-dependent manner.

In this study, a dichloromethane fraction (DCMF) from 70% Auricularia auricula-judae ethanol extract showed the highest level of antitumor activity compared to other solvent fractions (ethyl acetate, butanol, and water).